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A Survey of siRNA Nanoscale Delivery Patents
Volume 11, Issue 1

Christopher E. Loh and April Breyer

Small interfering RNA (“siRNA”) therapy uses small molecules designed to pair with the sequence of messenger RNA that encodes disease-related proteins. The biotechnology industry has applied for and received hundreds of U.S. patents related to the nanoscale technologies to help with effective siRNA delivery. For example, Tekmira Pharmaceuticals has a patent portfolio for its lipidoid nanoparticle siRNA delivery technology, while Arrowhead Research has obtained patents covering its RONDEL platform of self-assembled siRNA-containing nanoparticles. This article summarizes some of the most visible siRNA delivery technologies and their patents in the current landscape.

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